MODULATION OF NEUTROPHIL AND MONOCYTE FUNCTION BY RECOMBINANT HUMAN GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTOR IN PATIENTS WITH LYMPHOMA

被引:24
作者
KHARAZMI, A [1 ]
NIELSEN, H [1 ]
HOVGAARD, D [1 ]
BORREGAARD, N [1 ]
NISSEN, NI [1 ]
机构
[1] RIGSHOSP 7806,DEPT MED & HAEMATOL,DK-2200 COPENHAGEN N,DENMARK
关键词
CHEMILUMINESCENCE; CHEMOTAXIS; GM-CSF; LYMPHOMA; MONOCYTE; NEUTROPHIL;
D O I
10.1111/j.1365-2362.1991.tb01813.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Granulocyte macrophage colony-stimulating factor (GM-CSF) has been shown to inhibit the chemotaxis and enhance the oxidative burst response of human neutrophils in vitro. The present study describes the effect of recombinant GM-CSF on the neutrophil and monocyte function in patients with lymphoma undergoing GM-CSF treatment. Patients with either Hodgkin's or non-Hodgkin's lymphoma were treated with various dosages (2-16-mu-g kg-1 body weight per day for 5 days) of rhGM-CSF by intravenous or subcutaneous route. Prior to and on day 5 of rhGM-CSF treatment, neutrophil and monocyte chemotaxis and chemiluminescence responses to f-Met-Leu-Phe, zymosan activated serum (ZAS) and opsonized zymosan (OZ) were determined. It was observed that chemotactic response of neutrophils to f-Met-Leu-Phe and ZAS was reduced, whereas the chemiluminescence response of both cell types to f-Met-Leu-Phe and zymosan was enhanced by up to 43-fold. rhGM-CSF treatment did not affect degranulation of the neutrophils as measured by release of vitamin B-12 binding protein. Degree of modulation of neutrophil and monocyte function by rhGM-CSF was independent of rhGM-CSF dosages administered. These data suggest that phagocytic defence system may be enhanced by GM-CSF treatment and that this cytokine may be a useful therapeutic adjunct in compromised patients.
引用
收藏
页码:219 / 224
页数:6
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