SYNTHESES OF THE POTENT INHIBITORS OF NEURAMINIDASE, N-(1,2-DIHYDROXYPROPYL) DERIVATIVES OF SIASTATIN-B AND ITS 4-DEOXY ANALOGS

被引：17

作者：

KUDO, T ^{[1
]}

NISHIMURA, Y ^{[1
]}

KONDO, S ^{[1
]}

TAKEUCHI, T ^{[1
]}

机构：

[1] INST MICROBIAL CHEM,3-14-23 KAMIOSAKI,SHINAGAWA KU,TOKYO 141,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 02期

关键词：

D O I：

10.7164/antibiotics.46.300

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Potent inhibitors of neuraminidase, 3,4-didehydro-4-deoxysiastatin B, 4-deoxysiastatin B and N-[(S and R)-1,2-dihydroxypropyl] derivatives of siastatin B, 3,4-didehydro-4-deoxysiastatin B and 4-deoxysiastatin B have been synthesized by the chemical modifications of siastatin B.

引用

页码：300 / 309

页数：10

共 16 条

[1] METHODS FOR QUANTITATIVE ESTIMATION OF N-ACETYLNEURAMINIC ACID AND THEIR APPLICATION TO HYDROLYSATES OF SIALOMUCOIDS [J].

AMINOFF, D .

BIOCHEMICAL JOURNAL, 1961, 81 (02) :384-&

[2] AMYLASES, ALPHA AND BETA [J].

BERNFELD, P .

METHODS IN ENZYMOLOGY, 1955, 1 :149-158

[3] THE DEVELOPMENT AND USE OF QUANTUM-MECHANICAL MOLECULAR-MODELS .76. AM1 - A NEW GENERAL-PURPOSE QUANTUM-MECHANICAL MOLECULAR-MODEL [J].

DEWAR, MJS ;

ZOEBISCH, EG ;

HEALY, EF ;

STEWART, JJP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (13) :3902-3909

[4] THE PURIFICATION AND PROPERTIES OF AN ALPHA-GLUCOSIDASE OF SACCHAROMYCES-ITALICUS-Y1225 [J].

HALVORSON, H ;

ELLIAS, L .

BIOCHIMICA ET BIOPHYSICA ACTA, 1958, 30 (01) :28-40

[5] TOTALLY SYNTHETIC ANALOGS OF SIASTATIN-B .1. OPTICALLY-ACTIVE 2-ACETAMIDOPIPERIDINE DERIVATIVES [J].

KUDO, T ;

NISHIMURA, Y ;

KONDO, S ;

TAKEUCHI, T .

JOURNAL OF ANTIBIOTICS, 1992, 45 (06) :954-962

[6] SYNTHESES AND ACTIVITIES OF N-SUBSTITUTED DERIVATIVES OF SIASTATIN-B [J].

KUDO, T ;

NISHIMURA, Y ;

KONDO, S ;

TAKEUCHI, T .

JOURNAL OF ANTIBIOTICS, 1992, 45 (10) :1662-1668

[7] 2-DEOXY-2,3-DEHYDROSIALIC ACIDS, .2. COMPETIVE INHIBITION OF VIBRIO CHOLERAE NEURAMINIDASE BY 2-DEOXY-2,3-DEHYDRO-N-ACYLNEURAMINIC ACIDS [J].

MEINDL, P ;

TUPPY, H .

HOPPE-SEYLERS ZEITSCHRIFT FUR PHYSIOLOGISCHE CHEMIE, 1969, 350 (09) :1088-&

[8] SIASTATIN-B, A POTENT NEURAMINIDASE INHIBITOR - THE TOTAL SYNTHESIS AND ABSOLUTE-CONFIGURATION [J].

NISHIMURA, Y ;

WANG, W ;

KONDO, S ;

AOYAGI, T ;

UMEZAWA, H .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1988, 110 (21) :7249-7250

[9] TOTAL SYNTHESIS OF SIASTATIN-B AND ITS ENANTIOMER USING CARBOHYDRATE AS A CHIRAL EDUCT [J].

NISHIMURA, Y ;

WANG, WM ;

KUDO, T .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1992, 65 (04) :978-986

[10] TOTALLY SYNTHETIC ANALOGS OF SIASTATIN-B .2. OPTICALLY-ACTIVE PIPERIDINE-DERIVATIVES HAVING TRIFLUOROACETAMIDE AND HYDROXYACETAMIDE GROUPS AT C-2 [J].

NISHIMURA, Y ;

KUDO, T ;

KONDO, S ;

TAKEUCHI, T .

JOURNAL OF ANTIBIOTICS, 1992, 45 (06) :963-970

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