INTRACEREBRAL 1S,3R-1-AMINOCYCLOPENTANE-1,3-DICARBOXYLIC ACID (1S,3R-ACPD) PRODUCES LIMBIC SEIZURES THAT ARE NOT BLOCKED BY IONOTROPIC GLUTAMATE-RECEPTOR ANTAGONISTS

被引：50

作者：

TIZZANO, JP ^{[1
]}

GRIFFEY, KI ^{[1
]}

JOHNSON, JA ^{[1
]}

FIX, AS ^{[1
]}

HELTON, DR ^{[1
]}

SCHOEPP, DD ^{[1
]}

机构：

[1] ELI LILLY & CO,DIV CENT NERVOUS SYST,INDIANAPOLIS,IN 46285

来源：

NEUROSCIENCE LETTERS | 1993年 / 162卷 / 1-2期

关键词：

EXCITATORY AMINO ACID; METABOTROPIC GLUTAMATE RECEPTOR; 1S; 3R-ACPD; LIMBIC SEIZURE; MOUSE;

D O I：

10.1016/0304-3940(93)90548-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The functional role of metabotropic glutamate receptor (mGluR) activation was investigated following intracerebral administration of 1S,3R-ACPD in mice. Injections of 1S,3R-ACPD (50-800 nmol in 5 mul) into the thalamus produced a dose-dependent increase in limbic seizures. These effects were stereoselective since 1R,3S-ACPD, did not elicit seizure activity. Pharmacologically, limbic seizures were attenuated by the mGluR partial agonist/antagonist L-2-amino-3-phosphonopropionate (L-AP3) and dantrolene, an inhibitor of intracellular calcium mobilization, but not by D-AP3 or ionotropic glutamate receptor antagonists (MK-801 or GYKI-52466). Thus, activation of mGluRs by 1S,3R-ACPD in mice, induces limbic seizures that may involve the mobilization of intracellular calcium stores.

引用

页码：12 / 16

页数：5

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