INHIBITORY ACTIVITY OF ANTI-BETA(2)-GLYCOPROTEIN-I ANTIBODY ON FACTOR VA DEGRADATION BY ACTIVATED-PROTEIN-C AND ITS COFACTOR PROTEIN-S

被引：25

作者：

MATSUDA, J

GOHCHI, K

KAWASUGI, K

GOTOH, M

SAITOH, N

TSUKAMOTO, M

机构：

[1] Department of Medicine, Teikyo University School of Medicine, Tokyo

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 1995年 / 49卷 / 01期

关键词：

ANTI-BETA(2)-GLYCOPROTEIN I ANTIBODY; BETA(2)-GLYCOPROTEIN I; PROTEIN C; PROTEIN S; FACTOR VA;

D O I：

10.1002/ajh.2830490116

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated the influence of anti-beta(2)-glycoprotein I (aGPI), which recently has come to be regarded as anti-cardiolipin antibody (aCL) itself, on factor Va (FVa) degradation by activated protein C/protein S system, We found that aGPI had an inhibitory effect on FVa degradation with beta(2)-glycoprotein I-dependency, thus suggesting aGPI/aCL is a highly possible factor as the pathogenesis of thrombosis observed in aGPI/aCL-positive patients. (C) 1995 Wiley-Liss, Inc.

引用

页码：89 / 91

页数：3

共 9 条

[1]

BEVERS EM, 1991, THROMB HAEMOSTASIS, V66, P629

[2]

BRANDT JT, 1993, THROMB HAEMOSTASIS, V70, P598

[3] PROTEIN-C PATHWAY, ANTIPHOSPHOLIPID ANTIBODIES AND THROMBOSIS [J].