A TRICOMPONENT REACTION PROMOTED BY A TITANIUM TRICHLORIDE PYRIDINE SYSTEM DIASTEREOSELECTIVE SYNTHESIS OF BETA-AMINO-ALPHA-HYDROXYESTERS

被引:26
作者
CLERICI, A [1 ]
CLERICI, L [1 ]
PORTA, O [1 ]
机构
[1] POLITECN MILAN, DIPARTIMENTO CHIM, I-20131 MILAN, ITALY
关键词
D O I
10.1016/0040-4039(95)01151-7
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Methyl phenylglyoxylate, aniline and aromatic aldehydes, on treatment with TiCl3/pyridine in anhydrous THF at room temperature, undergo rapid condensation to produce syn-beta-amino-alpha-hydroxyesters. The mechanism of the reaction is rationalized.
引用
收藏
页码:5955 / 5958
页数:4
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