MACROLIDE ANTIBACTERIALS - DRUG-INTERACTIONS OF CLINICAL-SIGNIFICANCE

被引：155

作者：

VONROSENSTIEL, NA ^{[1
]}

ADAM, D ^{[1
]}

机构：

[1] UNIV MUNICH,DR VON HAUNERSCHEN KINDERSPITAL,ANTIMIKROBIELLE THERAPIE & INFEKT IMMUNOL ABT,D-80337 MUNICH,GERMANY

来源：

DRUG SAFETY | 1995年 / 13卷 / 02期

关键词：

D O I：

10.2165/00002018-199513020-00005

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Macrolide antibiotics can interact adversely with commonly used drugs, usually by altering metabolism due to complex formation and inhibition of cytochrome P-450 IIIA4 (CYP3A4) in the liver and enterocytes. In addition, pharmacokinetic drug interactions with macrolides can result from their antibiotic effect on microorganisms of the enteric flora, and through enhanced gastric emptying due to a motilin-like effect.

引用

页码：105 / 122

页数：18

共 229 条

[1]

Kirst H.A., New macrolides: expanded horizons for an old class of antibiotics, J Antimicrob Chemother, 28, (1991)

[2]

Fernandez P.B., The macrolide revival: thirty-five years after erythromycin, Antimicrob Newslett, 4, pp. 25-33, (1987)

[3]

Kirst H.A., Sides G.D., New directions for macrolide antibiotics: structural modifications and in vitro activity, Antimicrob Agents Chemother, 33, (1989)

[4]

Kirst H.A., Sides G.D., New directions for macrolide antibiotics: pharmacokinetics and clinical efficacy, Antimicrob Agents Chemother, 33, (1989)

[5]

Peters D.H., Clissold S.P., Clarithromycin: a review of its antimicrobial activity, pharmacokinetic properties and therapeutic potential, Drugs, 42, 1, (1992)

[6]

Peters D.H., Friedel H.A., McTavish D., Azithromycin: a review of its antimicrobial activity, pharmacokinetic properties and clinical efficacy, Drugs, 44, 5, (1992)

[7]

Young R.A., Gonzalez J.P., Sorkin E.M., Roxithromycin: a review of its antibacterial activity, pharmacokinetic properties and clinical efficacy, Drugs, 37, pp. 8-41, (1989)

[8]

Carver P.L., Clinically relevant drug interactions and adverse effects of antimicrobial agents, Curr Opin Infect Dis, 4, (1991)

[9]

Descotes J., Andre P., Evreux J.C., Pharmacokinetic drug interactions with macrolide antibiotics, J Antimicrob Chemother, 15, (1985)

[10]

Gillum J.G., Israel D.S., Polk R.E., Pharmacokinetic drug interactions with antimicrobial agents, Clin Pharmacokinet, 25, (1993)

← 1 2 3 4 5 6 7 8 9 10 →