MACROLIDE ANTIBACTERIALS - DRUG-INTERACTIONS OF CLINICAL-SIGNIFICANCE

被引：155

作者：

VONROSENSTIEL, NA ^{[1
]}

ADAM, D ^{[1
]}

机构：

[1] UNIV MUNICH,DR VON HAUNERSCHEN KINDERSPITAL,ANTIMIKROBIELLE THERAPIE & INFEKT IMMUNOL ABT,D-80337 MUNICH,GERMANY

来源：

DRUG SAFETY | 1995年 / 13卷 / 02期

关键词：

D O I：

10.2165/00002018-199513020-00005

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Macrolide antibiotics can interact adversely with commonly used drugs, usually by altering metabolism due to complex formation and inhibition of cytochrome P-450 IIIA4 (CYP3A4) in the liver and enterocytes. In addition, pharmacokinetic drug interactions with macrolides can result from their antibiotic effect on microorganisms of the enteric flora, and through enhanced gastric emptying due to a motilin-like effect.

引用

页码：105 / 122

页数：18

共 229 条

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