THROMBOPROPHYLAXIS WITH LOW-MOLECULAR-WEIGHT HEPARIN IN OUTPATIENTS WITH PLASTER-CAST IMMOBILIZATION OF THE LEG

被引：144

作者：

KOCK, HJ

SCHMITNEUERBURG, KP

HANKE, J

RUDOFSKY, G

HIRCHE, H

机构：

[1] UNIV HOSP ESSEN,INST MED INFORMAT,D-45122 ESSEN,GERMANY

[2] UNIV HOSP ESSEN,ANGIOL UNIT,D-45122 ESSEN,GERMANY

来源：

LANCET | 1995年 / 346卷 / 8973期

关键词：

D O I：

10.1016/S0140-6736(95)91320-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Deep-vein thrombosis is common after plaster-cast immobilisation for traumatic injury. We did a randomised prospective study of the effect of low-molecular-weight heparin on the incidence of deep-vein thrombosis in patients with minor injuries treated with plaster-cast immobilisation of the leg. A control group (n=163) received no prophylaxis, the prophylaxis group received low-molecular-weight heparin once daily (n=176). The incidence of deep-vein thrombosis in the prophylaxis group was 0% (one tailed p<0.006) vs 4.3% in the control group. No severe side-effects of low-molecular-weight heparin were observed. Thromboprophylaxis with low-molecular-weight heparin once dairy is effective in reducing the risk of deep-vein thrombosis in outpatients with plaster-cast immobilisation of the leg.

引用

页码：459 / 461

页数：3