INHIBITION OF HUMAN HERPESVIRUS-6 REPLICATION BY 9-[4-HYDROXY-2-(HYDROXYMETHYL)BUTYL]GUANINE (2HM-HBG) AND OTHER ANTIVIRAL COMPOUNDS

被引：39

作者：

AKESSONJOHANSSON, A ^{[1
]}

HARMENBERG, J ^{[1
]}

WAHREN, B ^{[1
]}

LINDE, A ^{[1
]}

机构：

[1] NATL BACTERIOL LAB,DEPT VIROL,S-10521 STOCKHOLM,SWEDEN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 12期

关键词：

D O I：

10.1128/AAC.34.12.2417

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro susceptibilities of human herpesvirus 6 to foscarnet; the guanosine analogs acyclovir, ganciclovir, and two isomers of 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine; and the thymidine analogs 3'-azido-3'-deoxythymidine and 1-β-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil were investigated. All compounds except 3'-azido-3'-deoxythymidine and 1-β-D-arabinofuranosyl-E-5-(2-bromovinyl)uracil inhibited human herpesvirus 6 replication. The highest in vitro selectivity was obtained for 9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine.

引用

页码：2417 / 2419

页数：3

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