IDENTIFICATION OF THE 23 KDA SUBUNIT OF TAU-PROTEIN KINASE-II AS A PUTATIVE ACTIVATOR OF CDK5 IN BOVINE BRAIN

被引：147

作者：

ISHIGURO, K ^{[1
]}

KOBAYASHI, S ^{[1
]}

OMORI, A ^{[1
]}

TAKAMATSU, M ^{[1
]}

YONEKURA, S ^{[1
]}

ANZAI, K ^{[1
]}

IMAHORI, K ^{[1
]}

UCHIDA, T ^{[1
]}

机构：

[1] NIHON UNIV, COLL PHARM, FUNABASHI, CHIBA 274, JAPAN

来源：

FEBS LETTERS | 1994年 / 342卷 / 02期

关键词：

TAU PROTEIN; PAIRED HELICAL FILAMENT; ALZHEIMERS DISEASE; CYCLIN-DEPENDENT KINASE 5; TAG SEQUENCE;

D O I：

10.1016/0014-5793(94)80501-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tau protein kinase II (TPKII) was reported previously to be composed of a neuron-rich cdc2-related kinase (PSSALRE/cdk5) and 23 kDa subunit. Here we show that the 23 kDa subunit is a putative activator for the kinase activity. Amino acid sequence analysis revealed that the protein was novel and included a partial similarity of amino acids to a cyclin box important for the interaction with cdc2-related kinase. These results suggest that the 23 kDa subunit, but not cyclin, activates cdk5 in neuronal cells, which no longer exhibit cell cycling but are terminally differentiated cells.

引用

页码：203 / 208

页数：6

共 34 条

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