ANTIDEPRESSANT-LIKE EFFECT OF SELECTIVE DOPAMINE D-1 RECEPTOR AGONISTS IN THE BEHAVIORAL DESPAIR ANIMAL-MODEL OF DEPRESSION

被引：59

作者：

DAQUILA, PS

COLLU, M

PANI, L

GESSA, GL

SERRA, G

机构：

[1] UNIV CAGLIARI,BB BRODIE DEPT NEUROSCI,I-09124 CAGLIARI,ITALY

[2] UNIV CAGLIARI,CNR,CTR NEUROPHARMACOL,I-09124 CAGLIARI,ITALY

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 262卷 / 1-2期

关键词：

DOPAMINE D-1 RECEPTOR AGONIST; ANTIDEPRESSANT EFFECT; BEHAVIORAL DESPAIR;

D O I：

10.1016/0014-2999(94)90033-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We compared the effect of two selective dopamine D-1 receptor agonists, SKF 38393 ((+/-)-1-phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol HCl) and A68930 ((1 R,3S)-1-aminomethyl-5,6-dihydroxy-3-phenlisochroman.HCl), and;that of imipramine in the behavioural despair model of depression. The dopamine D-1 receptor agonists and imipramine showed an anti-immobility effect. Moreover we found that the 'antidepressant' effect of imipramine in the behavioural despair test was antagonized by SCH 23390, a selective dopamine D-1 receptor blocker. The results further support the hypothesis that dopamine D-1 receptor stimulation plays an important role in the mechanism of action of antidepressants and suggest that dopamine D-1 receptor agonists might be considered as potential antidepressant drugs.

引用

页码：107 / 111

页数：5

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