TUMOR-NECROSIS-FACTOR PRODUCTION IN CATS IN RESPONSE TO LIPOPOLYSACCHARIDE - AN IN-VIVO AND IN-VITRO STUDY

被引：16

作者：

OTTO, CM ^{[1
]}

RAWLINGS, CA ^{[1
]}

机构：

[1] UNIV GEORGIA,DEPT SMALL ANIM MED,ATHENS,GA 30602

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1995年 / 49卷 / 1-2期

关键词：

TUMOR NECROSIS FACTOR; LIPOPOLYSACCHARIDE; FELINE;

D O I：

10.1016/0165-2427(95)05456-G

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Supernatants from feline peritoneal exudate cells (PECs) exposed to lipopolysaccharde (LPS) produced significantly (P < 0.05) more tumor necrosis factor (TNF) activity than supernatants from cells exposed to media. An in vitro LPS response was obtained following incubation of whole blood with 10 mu g ml(-1) LPS for 2 h. Intravenous infusion of LPS (750 mu g kg(-1)) rapidly increased plasma TNF activity to a maximum at 60 min after initiation of LPS infusion. By 180 min, TNF activity returned to baseline. Cats produce TNF in response to LPS in a manner similar to other species. Measurement of TNF activity in plasma or in LPS-stimulated whole blood are methods to further characterize the inflammatory response in feline diseases.

引用

页码：183 / 188

页数：6

共 17 条

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COHEN S, 1992, LYMPHOKINE CYTOK RES, V11, P215

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