ENZYME ISOLATED FROM ARTERIES TRANSFORMS PROSTAGLANDIN ENDOPEROXIDES TO AN UNSTABLE SUBSTANCE THAT INHIBITS PLATELET-AGGREGATION

被引：3667

作者：

MONCADA, S ^{[1
]}

GRYGLEWSKI, R ^{[1
]}

BUNTING, S ^{[1
]}

VANE, JR ^{[1
]}

机构：

[1] WELLCOME RES LABS, BECKENHAM BR3 3BS, KENT, ENGLAND

来源：

NATURE | 1976年 / 263卷 / 5579期

关键词：

D O I：

10.1038/263663a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

引用

页码：663 / 665

页数：3

共 24 条

[11]

KITCHENS CS, 1975, BLOOD, V46, P567

[12]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[13] PROSTAGLANDIN ENDOPEROXIDES .8. PHYSIOLOGICAL-ROLE OF AN ENDOPEROXIDE IN HUMAN PLATELETS - HEMOSTATIC DEFECT DUE TO PLATELET CYCLO-OXYGENASE DEFICIENCY [J].

MALMSTEN, C ;

HAMBERG, M ;

SVENSSON, J ;

SAMUELSSON, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (04) :1446-1450

[14] PLATELET FUNCTION .I. [J].

MARCUS, AJ .

NEW ENGLAND JOURNAL OF MEDICINE, 1969, 280 (22) :1213-+

[15]

MONCADA S, IN PRESS

[16]

NEEDLEMAN P, 1976, NATURE, V261, P550

[17] ISOLATION AND PROPERTIES OF INTERMEDIATES IN PROSTAGLANDIN BIOSYNTHESIS [J].

NUGTEREN, DH ;

HAZELHOF, E .

BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 326 (03) :448-461

[18] RELEASE OF RABBIT AORTA CONTRACTING SUBSTANCE (RCS) AND PROSTAGLANDINS INDUCED BY CHEMICAL OR MECHANICAL STIMULATION OF GUINEA-PIG LUNGS [J].

PALMER, MA ;

PIPER, PJ ;

VANE, JR .

BRITISH JOURNAL OF PHARMACOLOGY, 1973, 49 (02) :226-242

[19] RELEASE OF ADDITIONAL FACTORS IN ANAPHYLAXIS AND ITS ANTAGONISM BY ANTI-INFLAMMATORY DRUGS [J].

PIPER, PJ ;

VANE, JR .

NATURE, 1969, 223 (5201) :29-&

[20]

ROY AJ, 1972, P SOC EXP BIOL MED, V139, P137

← 1 2 3 →