REGULATION OF PLANT GENE-EXPRESSION BY ANTISENSE RNA

被引：88

作者：

MOL, JNM

VANDERKROL, AR

VANTUNEN, AJ

VANBLOKLAND, R

DELANGE, P

STUITJE, AR

机构：

[1] Department of Genetics, Vrije Universiteit, 1081 HV Amsterdam

来源：

FEBS LETTERS | 1990年 / 268卷 / 02期

关键词：

Antisense RNA; Co-suppression; Gene interaction; Gene silencing; Sense RNA;

D O I：

10.1016/0014-5793(90)81298-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulation of gene expression by antisense RNA was first discovered as a naturally-occurring phenomenon in bacteria. Recently natural antisense RNAs have been found in a variety of eukaryotic organisms; their in vivo function is, however, obscure. Deliberate expression of antisense RNA in animal and plant systems has lead to successful down-regulation of specific genes. We will review the current status of antisense gene action in plant systems. The recent discovery that 'sense' genes are able to mimic the action of antisense genes indicates that (anti)sense genes must operate by mechanisms other than RNA-RNA interaction. © 1990.

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页码：427 / 430

页数：4

相关论文

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