SUSCEPTIBILITY TESTING OF LISTERIA-MONOCYTOGENES - A REASSESSMENT OF BACTERICIDAL ACTIVITY AS A PREDICTOR FOR CLINICAL OUTCOME

被引:17
作者
APPLEMAN, MD
CHERUBIN, CE
HESELTINE, PNR
STRATTON, CW
机构
[1] VANDERBILT UNIV,MED CTR,DEPT PATHOL,C-3217 MCN,NASHVILLE,TN 37232
[2] UNIV SO CALIF,LOS ANGELES CTY MED CTR,DEPT PATHOL,LOS ANGELES,CA 90033
[3] UNIV SO CALIF,LOS ANGELES CTY MED CTR,DEPT MED,LOS ANGELES,CA 90033
[4] MERCY HOSP & MED CTR,DEPT MED,CHICAGO,IL 60616
[5] UNIV ILLINOIS,DEPT MED,INFECT DIS SECT,CHICAGO,IL 60680
关键词
D O I
10.1016/0732-8893(91)90022-8
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
In vitro susceptibility testing of Listeria monocytogenes most often reveals both ampicillin and penicillin as inhibitory as opposed to bactericidal with activity comparable to chloramphenicol and tetracycline. Yet, the former two penicillins are more effective for Listeria meningitis than are the latter agents. Accordingly, we reassessed the bactericidal activity of agents used in listeriosis in order to determine in vitro methodology that would be more predictive of clinical outcome. We found that bactericidal activity for > 48 hr by either minimum inhibitory-minimum bactericidal concentration (MIC-MBC) testing or time-kill kinetic studies was the best predictor of clinical efficacy. This correlation may be due to Listeria being a slow-growing microorganism. In addition to ampicillin and penicillin, we found trimethoprim-sulfamethoxazole, vancomycin, and imipenem to exhibit bactericidal activity for 48 hr. For the first two agents, this is in agreement with the results of clinical experience.
引用
收藏
页码:311 / 317
页数:7
相关论文
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