SYNTHETIC APPROACHES TOWARDS NUCLEOCIDIN AND SELECTED ANALOGS - ANTI-HIV ACTIVITY IN 4'-FLUORINATED NUCLEOSIDE DERIVATIVES

被引：38

作者：

MAGUIRE, AR

MENG, WD

ROBERTS, SM

WILLETTS, AJ

机构：

[1] UNIV EXETER,DEPT CHEM,EXETER EX4 4RJ,DEVON,ENGLAND

[2] UNIV EXETER,DEPT BIOL SCI,EXETER EX4 4RJ,DEVON,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 15期

关键词：

D O I：

10.1039/p19930001795

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Nucleocidin 1 has been synthesised from the adenosine derivative 4 via the intermediacy of the dihalogeno compound 9. The latter compound showed slight but significant activity against HIV-infected cells while the isomer 10 and the monohalogeno compound 60 were inactive. Synthetic approaches towards other 4'-fluorinated nucleoside derivatives are also described. The epimeric 4'-fluorinated nucleosides 26 and 27 displayed similar activity against HIV-infected cells to that observed for the dihalogenated compound 9.

引用

页码：1795 / 1808

页数：14