STRUCTURE AND CHROMOSOMAL MAPPING OF GENES FOR THE MOUSE KAPPA-OPIOID RECEPTOR AND AN OPIOID RECEPTOR HOMOLOG (MOR-C)

被引：97

作者：

NISHI, M

TAKESHIMA, H

MORI, M

NAKAGAWARA, K

TAKEUCHI, T

机构：

[1] TOKYO INST PSYCHIAT,DEPT NEUROCHEM,SETAGAYA KU,TOKYO 156,JAPAN

[2] CLUSTER CORE INC,SENDAI,MIYAGI 983,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 205卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.2814

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent cDNA cloning studies have defined four members of the opioid receptor family, i.e., delta-, mu- and kappa-subtypes, and an opioid receptor homologue for unknown ligands. In this report, we isolated and analyzed mouse genomic DNA segments containing the kappa-opioid receptor gene and a gene for the opioid receptor homologue (designated as MOR-C). The genes are closely related each other in exon-intron organization, suggesting their evolutional relationship. Using in situ hybridization, we show that the kappa-opioid receptor gene and the MOR-C gene map to mouse chromosome 1A2-3 and 2H2-4, respectively.

引用

页码：1353 / 1357

页数：5

共 22 条

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