ISOLATION AND CHARACTERIZATION OF NEW 18-MEMBERED MACROLIDES FD-891 AND FD-892

被引：28

作者：

SEKIASANO, M ^{[1
]}

OKAZAKI, T ^{[1
]}

YAMAGISHI, M ^{[1
]}

SAKAI, N ^{[1
]}

HANADA, K ^{[1
]}

MIZOUE, K ^{[1
]}

机构：

[1] TAISHO PHARMACEUT CO LTD,RES CTR,DEPT APPL BIOL,OMIYA,SAITAMA 330,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1994年 / 47卷 / 11期

关键词：

D O I：

10.7164/antibiotics.47.1226

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New 18-membered macrolides FD-891 and FD-892 were discovered from the fermentation broth of Streptomyces graminofaciens A-8890 isolated from a soil sample collected at Yamanashi prefecture, Japan. They induce morophological changes of HL-60 cells at low concentration below IC(50)s and have cytocidal activity against in vitro tumor cell lines. FD-891 showed 2 similar to 7 times stronger activity than doxorubicin whereas FD-892 was 20 similar to 100 fold weaker than FD-891 and doxorubicin.

引用

页码：1226 / 1233

页数：8

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