A GENE IN THE CHROMOSOMAL REGION 3P21 WITH GREATLY REDUCED EXPRESSION IN LUNG-CANCER IS SIMILAR TO THE GENE FOR UBIQUITIN-ACTIVATING ENZYME

被引：89

作者：

KOK, K

HOFSTRA, R

PILZ, A

VANDENBERG, A

TERPSTRA, P

BUYS, CHCM

CARRITT, B

机构：

[1] UNIV LONDON UNIV COLL,MRC,HUMAN BIOCHEM GENET UNIT,LONDON NW1 2HE,ENGLAND

[2] UNIV GRONINGEN,CTR BIOMED TECHNOL,9713 EZ GRONINGEN,NETHERLANDS

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 13期

关键词：

D O I：

10.1073/pnas.90.13.6071

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.

引用

页码：6071 / 6075

页数：5

共 30 条

[1] EXPRESSION, NUCLEOTIDE-SEQUENCE AND MUTATIONAL ANALYSIS OF 2 OPEN READING FRAMES IN THE NIF GENE REGION OF ANABAENA SP STRAIN PCC-7120
BORTHAKUR, D
BASCHE, M
BUIKEMA, WJ
BORTHAKUR, PB
HASELKORN, R
[J]. MOLECULAR AND GENERAL GENETICS, 1990, 221 (02): : 227 - 234
[2] MOLECULAR ANALYSIS OF THE SHORT ARM OF CHROMOSOME-3 IN SMALL-CELL AND NON-SMALL-CELL CARCINOMA OF THE LUNG
BRAUCH, H
JOHNSON, B
HOVIS, J
YANO, T
GAZDAR, A
PETTENGILL, OS
GRAZIANO, S
SORENSON, GD
POIESZ, BJ
MINNA, J
LINEHAN, M
ZBAR, B
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1987, 317 (18) : 1109 - 1113
[3] CARRITT B, 1992, CANCER RES, V52, P1536
[4] UBIQUITIN DEPENDENCE OF SELECTIVE PROTEIN-DEGRADATION DEMONSTRATED IN THE MAMMALIAN-CELL CYCLE MUTANT TS85
CIECHANOVER, A
FINLEY, D
VARSHAVSKY, A
[J]. CELL, 1984, 37 (01) : 57 - 66
[5] CIECHANOVER A, 1991, P NATL ACAD SCI USA, V88, P138
[6] ASSOCIATION OF UBIQUITIN-ACTIVATING ENZYME WITH HELA-CELL CHROMOSOMES DURING MITOSIS
COOK, JC
CHOCK, PB
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (24) : 11388 - 11392
[7] THERMOLABILITY OF UBIQUITIN-ACTIVATING ENZYME FROM THE MAMMALIAN-CELL CYCLE MUTANT TS85
FINLEY, D
CIECHANOVER, A
VARSHAVSKY, A
[J]. CELL, 1984, 37 (01) : 43 - 55
[8] MOLECULAR-CLONING, SEQUENCE, AND TISSUE DISTRIBUTION OF THE HUMAN UBIQUITIN-ACTIVATING ENZYME-E1
HANDLEY, PM
MUECKLER, M
SIEGEL, NR
CIECHANOVER, A
SCHWARTZ, AL
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (01) : 258 - 262
[9] HANDLEY PM, 1991, P NATL ACAD SCI USA, V88, P7456
[10] HATFIELD PM, 1990, J BIOL CHEM, V265, P15813

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