ANTICONVULSANT PROPERTIES OF D-20443 IN GENETICALLY EPILEPSY-PRONE RATS - PREDICTION OF CLINICAL-RESPONSE

被引:61
作者
DAILEY, JW [1 ]
CHEONG, JH [1 ]
KO, KH [1 ]
ADAMSCURTIS, LE [1 ]
JOBE, PC [1 ]
机构
[1] SEOUL NATL UNIV,COLL PHARM,CTR BIOFUNCT MOLEC,POSTECH,SEOUL,SOUTH KOREA
关键词
ANTIEPILEPTIC DRUGS; GENETICALLY EPILEPSY-PRONE RATS; SOUND-INDUCED SEIZURES; TONIC CLONIC SEIZURES; ABSENCE SEIZURES;
D O I
10.1016/0304-3940(95)11783-S
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
D-20443 is an experimental antiepileptic drug. Its mechanism of antiepileptic action is unknown. We evaluated the anticonvulsant effectiveness of D-20443 against sound-induced seizures in genetically epilepsy-prone rats (GEPRs). This compound produced anticonvulsant effects against sound-induced seizures in moderate seizure GEPRs (GEPR-3s) at significantly lower doses than in severe seizure GEPRs (GEPR-9s). Based on these data and on the responses of GEPRs to other antiepileptic drugs, we predict that D-20443 will be a broad spectrum antiepileptic agent in humans. That is, we predict that D-20443 will suppress both tonic/clonic and absence seizures in humans.
引用
收藏
页码:77 / 80
页数:4
相关论文
共 37 条
  • [1] BOOKER JG, 1986, LIFE SCI, V39, P799
  • [2] BROWNING RA, 1989, J PHARMACOL EXP THER, V249, P229
  • [3] ELECTROSHOCK-INDUCED AND PENTYLENETETRAZOL-INDUCED SEIZURES IN GENETICALLY EPILEPSY-PRONE RATS (GEPRS) - DIFFERENCES IN THRESHOLD AND PATTERN
    BROWNING, RA
    WANG, C
    LANKER, ML
    JOBE, PC
    [J]. EPILEPSY RESEARCH, 1990, 6 (01) : 1 - 11
  • [4] INJECTIONS OF NORADRENERGIC AND GABAERGIC AGONISTS INTO THE INFERIOR COLLICULUS - EFFECTS ON AUDIOGENIC-SEIZURES IN GENETICALLY EPILEPSY-PRONE RATS
    BROWNING, RA
    LANKER, ML
    FAINGOLD, CL
    [J]. EPILEPSY RESEARCH, 1989, 4 (02) : 119 - 125
  • [5] SEROTONERGIC ABNORMALITIES IN THE CENTRAL-NERVOUS-SYSTEM OF SEIZURE-NAIVE GENETICALLY EPILEPSY-PRONE RATS
    DAILEY, JW
    MISHRA, PK
    KO, KH
    PENNY, JE
    JOBE, PC
    [J]. LIFE SCIENCES, 1992, 50 (04) : 319 - 326
  • [6] NORADRENERGIC ABNORMALITIES IN THE CENTRAL-NERVOUS-SYSTEM OF SEIZURE-NAIVE GENETICALLY EPILEPSY-PRONE RATS
    DAILEY, JW
    MISHRA, PK
    KO, KH
    PENNY, JE
    JOBE, PC
    [J]. EPILEPSIA, 1991, 32 (02) : 168 - 173
  • [7] NEUROBIOLOGY OF SEIZURE PREDISPOSITION IN THE GENETICALLY EPILEPSY-PRONE RAT
    DAILEY, JW
    REIGEL, CE
    MISHRA, PK
    JOBE, PC
    [J]. EPILEPSY RESEARCH, 1989, 3 (01) : 3 - 17
  • [8] THE ANTICONVULSANT EFFECT OF THE BROAD-SPECTRUM ANTICONVULSANT LORECLEZOLE MAY BE MEDIATED IN PART BY SEROTONIN IN RATS - A MICRODIALYSIS STUDY
    DAILEY, JW
    SEO, DO
    YAN, QS
    KO, KH
    JO, MJ
    JOBE, PC
    [J]. NEUROSCIENCE LETTERS, 1994, 178 (02) : 179 - 183
  • [9] DAILEY JW, 1985, FED PROC, V44, P2640
  • [10] ENZYME-ACTIVITIES IN THE CENTRAL NERVOUS-SYSTEM OF THE EPILEPSY-PRONE RAT
    DAILEY, JW
    BATTARBEE, HD
    JOBE, PC
    [J]. BRAIN RESEARCH, 1982, 231 (01) : 225 - 230