VIRAL ESCAPE BY SELECTION OF CYTOTOXIC T-CELL-RESISTANT VIRUS VARIANTS INVIVO

被引：519

作者：

PIRCHER, H ^{[1
]}

MOSKOPHIDIS, D ^{[1
]}

ROHRER, U ^{[1
]}

BURKI, K ^{[1
]}

HENGARTNER, H ^{[1
]}

ZINKERNAGEL, RM ^{[1
]}

机构：

[1] SANDOZ PHARMA LTD, PRECLIN RES, CH-4002 BASEL, SWITZERLAND

来源：

NATURE | 1990年 / 346卷 / 6285期

关键词：

D O I：

10.1038/346629a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Viruses persist in an immune population, as in the case of influenza, or in an individual, as postulated for human immunodeficiency virus, when they are able to escape existent neutralizing antibody responses by changing their antigens. It is now shown that viruses can in principle escape the immunosurveillance of virus-specific cytotoxic T cells by mutations that alter the relevant T-cell epitope. © 1990 Nature Publishing Group.

引用

页码：629 / 633

页数：5

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