ASYMMETRIC-SYNTHESIS OF HOMOCHIRAL SYN-3-PHENYLISOSERINE AND ANTI-3-PHENYLISOSERINE DERIVATIVES - A PRACTICAL STRATEGY FOR THE SYNTHESIS OF THE TAXOL C-13 SIDE-CHAIN

被引：86

作者：

BUNNAGE, ME

DAVIES, SG

GOODWIN, CJ

机构：

[1] DYSON PERRINS LAB,S PARKS RD,OXFORD OX1 3QY,ENGLAND

[2] FISONS PLC,DIV PHARMACEUT,RES DEV LABS,LOUGHBOROUGH LE11 0RH,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1993年 / 13期

关键词：

D O I：

10.1039/p19930001375

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A tandem lithium amide conjugate addition-electrophilic hydroxylation approach to the synthesis of N-benzoyl-3-phenylisoserine methyl esters affords a strategy for the practical synthesis of the taxol side chain.

引用

页码：1375 / 1376

页数：2

共 20 条

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