ENZYMATIC OPTICAL RESOLUTION OF ALPHA,ALPHA-DIFLUORO-BETA-HYDROXYKETONES

被引：7

作者：

TSUKAMOTO, T ^{[1
]}

YAMAZAKI, T ^{[1
]}

KITAZUME, T ^{[1
]}

机构：

[1] TOKYO INST TECHNOL,DEPT BIOENGN,MEGURO KU,TOKYO 152,JAPAN

来源：

SYNTHETIC COMMUNICATIONS | 1990年 / 20卷 / 20期

关键词：

D O I：

10.1080/00397919008051543

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Kinetic resolution of various α,α-difluoro-β- hydroxyketones was conducted by enantioselective hydrolysis of the corresponding acetates with lipase MY to afford optically active products. Both enantiomers of 3,3-difluoro-2-hydroxy-4-decanone were obtained in a highly enantioselective manner by screening enzymes and acyl groups. © 1990, Taylor & Francis Group, LLC. All rights reserved.

引用

页码：3181 / 3186

页数：6

共 18 条

[1] FLUORO KETONE CONTAINING PEPTIDES AS INHIBITORS OF HUMAN RENIN
FEARON, K
SPALTENSTEIN, A
HOPKINS, PB
GELB, MH
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (09) : 1617 - 1622
[2] FLUORO KETONE INHIBITORS OF HYDROLYTIC ENZYMES
GELB, MH
SVAREN, JP
ABELES, RH
[J]. BIOCHEMISTRY, 1985, 24 (08) : 1813 - 1817
[3] BIOLOGICAL RESOLUTION OF RACEMIC 2-OXAZOLIDINONES .2. ASYMMETRIC HYDROLYSIS OF RACEMIC 2-OXAZOLIDINONE ESTERS WITH LIPASES
HAMAGUCHI, S
ASADA, M
HASEGAWA, J
WATANABE, K
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1984, 48 (09): : 2331 - 2337
[4] BIOLOGICAL RESOLUTION OF RACEMIC 2-OXAZOLIDINONES .1. ASYMMETRIC HYDROLYSIS OF (R,S)-5-ACETOXYMETHYL-3-TERT-BUTYL-OXAZOLIDIN-2-ONE WITH ENZYMES AND MICROORGANISMS
HAMAGUCHI, S
HASEGAWA, J
KAWAHARADA, H
WATANABE, K
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1984, 48 (08): : 2055 - 2059
[5] BIOLOGICAL RESOLUTION OF RACEMIC 2-OXAZOLIDINONES .4. ENZYMATIC RESOLUTION OF 2-OXAZOLIDINONE ESTERS
HAMAGUCHI, S
YAMAMURA, H
HASEGAWA, J
WATANABE, K
[J]. AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1985, 49 (05): : 1509 - 1511
[6] SYNTHESIS OF 2-DEOXY-2,2-DIFLUORO-D-RIBOSE AND 2-DEOXY-2,2-DIFLUORO-D-RIBOFURANOSYL NUCLEOSIDES
HERTEL, LW
KROIN, JS
MISNER, JW
TUSTIN, JM
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1988, 53 (11) : 2406 - 2409
[7] EXTENDED BINDING INHIBITORS OF CHYMOTRYPSIN THAT INTERACT WITH LEAVING GROUP SUBSITES S1'-S3'
IMPERIALI, B
ABELES, RH
[J]. BIOCHEMISTRY, 1987, 26 (14) : 4474 - 4477
[8] INHIBITION OF SERINE PROTEASES BY PEPTIDYL FLUOROMETHYL KETONES
IMPERIALI, B
ABELES, RH
[J]. BIOCHEMISTRY, 1986, 25 (13) : 3760 - 3767
[9] ASYMMETRICAL REDUCTION OF PERFLUOROALKYLATED KETONES, KETOESTERS AND VINYL COMPOUNDS WITH BAKERS-YEAST
KITAZUME, T
ISHIKAWA, N
[J]. CHEMISTRY LETTERS, 1983, (02) : 237 - 238
[10] MICROBIAL APPROACH TO THE PRACTICAL MONOFLUORINATED CHIRAL SYNTHONS
KITAZUME, T
SATO, T
KOBAYASHI, T
LIN, JT
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1986, 51 (07) : 1003 - 1006

← 1 2 →