INFLUENCE OF BETA-CASOMORPHIN DERIVATIVES ON CHEMICALLY AND ELECTRICALLY INDUCED SEIZURES

被引：10

作者：

BECKER, A ^{[1
]}

GRECKSCH, G ^{[1
]}

MATTHIES, H ^{[1
]}

机构：

[1] ACAD SCI GDR,INST NEUROBIOL & BRAIN RES,O-3090 MAGDEBURG,GERMANY

来源：

PEPTIDES | 1991年 / 12卷 / 01期

关键词：

BETA-CASOMORPHIN PEPTIDES; PROCONVULSIVE AND ANTICONVULSIVE EFFECT; CHEMICALLY AND ELECTRICALLY INDUCED SEIZURES;

D O I：

10.1016/0196-9781(91)90164-K

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Derivatives of beta-casomorphin(1-5) at a dose level of 1-mu-mol/kg body weight were tested for their influence on pentylenetetrazol, picrotoxin, or electrically induced seizures after subcutaneous injection in mice. Tyr-Pro-Phe-D-Pro-Gly was found to facilitate pentylenetetrazol-evoked seizures, whereas desTyr derivatives Pro-Phe-D-Pro-Gly and Pro-Phe-Pyr exhibited anticonvulsant properties against those convulsions. The tripeptide was effective only 10 min after application. The beta-casomorphin derivative Pro-D-Phe-Pro-Gly was effective against electrically induced seizures. The protective action of this tetrapeptide lasted for about 5 h. Additionally, we tested the influence of orally administered Pro-Phe-D-Pro-Gly on pentylenetetrazol-induced seizures and Pro-D-Phe-Pro-Gly on electrically induced seizures. Both peptides were effective at a dose of 5-mu-mol/kg body weight.

引用

页码：43 / 45

页数：3