LGN1, A GENE THAT DETERMINES SUSCEPTIBILITY TO LEGIONELLA-PNEUMOPHILA, MAPS TO MOUSE CHROMOSOME-13

被引：66

作者：

DIETRICH, WF ^{[1
]}

DAMRON, DM ^{[1
]}

ISBERG, RR ^{[1
]}

LANDER, ES ^{[1
]}

SWANSON, MS ^{[1
]}

机构：

[1] TUFTS UNIV,SCH MED,HOWARD HUGHES MED INST,BOSTON,MA 02111

来源：

GENOMICS | 1995年 / 26卷 / 03期

关键词：

D O I：

10.1016/0888-7543(95)80161-E

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The intracellular pathogen Legionella pneumophila is unable to replicate in macrophages derived from most inbred mouse strains. Here, we report the mapping of a gene, called Lgn1, that determines whether mouse macrophages are permissive for the intracellular replication of L. pneumophila. Although Lgn1 has been previously reported to map to mouse chromosome 15, we show here that it actually maps to chromosome 13, between D13Mit128 and D13Mit70. In the absence of any regional candidates for Lgn1, this map position will facilitate positional cloning attempts directed at this gene. (C) 1995 Academic Press, Inc.

引用

页码：443 / 450

页数：8