HEMORHEOLOGIC AND COAGULATIVE PATTERN IN HYPERCHOLESTEROLEMIC SUBJECTS TREATED WITH LIPID-LOWERING DRUGS

被引：64

作者：

BO, M ^{[1
]}

BONINO, F ^{[1
]}

NEIROTTI, M ^{[1
]}

GOTTERO, M ^{[1
]}

PERNIGOTTI, L ^{[1
]}

MOLASCHI, M ^{[1
]}

FABRIS, F ^{[1
]}

机构：

[1] UNIV TURIN,INST GERONTOL,I-10124 TURIN,ITALY

来源：

ANGIOLOGY | 1991年 / 42卷 / 02期

关键词：

D O I：

10.1177/000331979104200204

中图分类号：

R6 [外科学];

学科分类号：

1002 [临床医学]; 100210 [外科学];

摘要：

The effects on the coagulative and rheologic pattern of two lipid-lowering drugs, bezafibrate and simvastatin, were studied in 36 hypercholesterolemic subjects. Patients were randomly divided into two groups (18 subjects each) and received bezafibrate R 400 mg/day or simvastatin 10-40 mg/day over a twelve week period. Besides a decrease in plasma fibrinogen and fibrinopeptide A (p < 0.001 both), bezafibrate induced a reduction of factor VIIc and VIIIc activity (p < 0.001 both), while antithrombin 3 activity was increased (p < 0.001) and the hemorheologic pattern was greatly improved (p < 0.001). Simvastatin caused a slight decrease in factor VIIIc activity and a moderate reduction of beta-thromboglobulin. The efficacy of bezafibrate in reducing the activation of the coagulative cascade and improving the hemorheologic pattern has been confirmed; the peculiar triglycerides- and fibrinogen-lowering effect of the drug, not observed with simvastatin, could be responsible for these modifications.

引用

页码：106 / 113

页数：8

共 21 条

[1]

BAKER IA, 1982, BRIT HEART J, V47, P470

[2]

INTERRELATIONSHIP OF PLASMA TRIGLYCERIDE AND COAGULANT FACTOR-VII LEVELS IN NORMOTRIGLYCERIDEMIC HYPERCHOLESTEROLEMIA [J].