THE EFFECT OF SYSTEMIC COCAINE ON SPONTANEOUS AND NOCICEPTIVELY EVOKED ACTIVITY OF NEURONS IN THE MEDIAL AND LATERAL THALAMUS

被引：10

作者：

BELCZYNSKI, CR

PERTOVAARA, A

MORROW, TJ

CASEY, KL

机构：

[1] VET ADM MED CTR,NEUROL SERV,NEUROL RES LABS,2215 FULLER RD,ANN ARBOR,MI 48105

[2] UNIV MICHIGAN,DEPT NEUROL,ANN ARBOR,MI 48109

[3] UNIV MICHIGAN,DEPT PHYSIOL,ANN ARBOR,MI 48109

[4] UNIV MICHIGAN,NEUROSCI PROGRAM,ANN ARBOR,MI 48109

来源：

BRAIN RESEARCH | 1990年 / 517卷 / 1-2期

关键词：

Analgesia; Cocaine; Electrophysiology; Nociception; Somatosensory; Thalamus; Unit analysis;

D O I：

10.1016/0006-8993(90)91048-L

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In rats, analgesic doses of cocaine (25 mg/kg, i.p.) suppressed the responses of 20 of 22 medial and lateral thalamic neurons to reticular formation and somatic noxious stimuli. The responses of 7 of 8 lateral thalamic neurons to innocuous somatic stimuli were unaffected or enhanced. The suppression of thalamic responses to noxious stimuli may be part of the mechanism underlying cocaine analgesia. © 1990.

引用

页码：344 / 346

页数：3

共 18 条

[1] ENDOGENOUS PAIN CONTROL MECHANISMS - REVIEW AND HYPOTHESIS [J].