THE EFFECT OF SYSTEMIC COCAINE ON SPONTANEOUS AND NOCICEPTIVELY EVOKED ACTIVITY OF NEURONS IN THE MEDIAL AND LATERAL THALAMUS

被引:10
作者
BELCZYNSKI, CR
PERTOVAARA, A
MORROW, TJ
CASEY, KL
机构
[1] VET ADM MED CTR,NEUROL SERV,NEUROL RES LABS,2215 FULLER RD,ANN ARBOR,MI 48105
[2] UNIV MICHIGAN,DEPT NEUROL,ANN ARBOR,MI 48109
[3] UNIV MICHIGAN,DEPT PHYSIOL,ANN ARBOR,MI 48109
[4] UNIV MICHIGAN,NEUROSCI PROGRAM,ANN ARBOR,MI 48109
关键词
Analgesia; Cocaine; Electrophysiology; Nociception; Somatosensory; Thalamus; Unit analysis;
D O I
10.1016/0006-8993(90)91048-L
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In rats, analgesic doses of cocaine (25 mg/kg, i.p.) suppressed the responses of 20 of 22 medial and lateral thalamic neurons to reticular formation and somatic noxious stimuli. The responses of 7 of 8 lateral thalamic neurons to innocuous somatic stimuli were unaffected or enhanced. The suppression of thalamic responses to noxious stimuli may be part of the mechanism underlying cocaine analgesia. © 1990.
引用
收藏
页码:344 / 346
页数:3
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