CLONING OF AN INTERLEUKIN-3 RECEPTOR GENE - A MEMBER OF A DISTINCT RECEPTOR GENE FAMILY

被引：425

作者：

ITOH, N

YONEHARA, S

SCHREURS, J

GORMAN, DM

MARUYAMA, K

ISHII, A

YAHARA, I

ARAI, K

MIYAJIMA, A

机构：

[1] DNAX RES INST MOLEC & CELLULAR BIOL INC,MOLEC & CELLULAR BIOL RES INST,DEPT MOLEC BIOL,PALO ALTO,CA 94304

[2] TOKYO METROPOLITAN INST MED SCI,DEPT CELL BIOL,BUNKYO KU,TOKYO 113,JAPAN

来源：

SCIENCE | 1990年 / 247卷 / 4940期

关键词：

D O I：

10.1126/science.2404337

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interleukin-3 (IL-3) binds to its receptor with high and low affinities, induces tyrosine phosphorylation, and promotes the proliferation and differentiation of hematopoietic cells. A binding component of the IL-3 receptor was cloned. Fibroblasts transfected with the complementary DNA bound IL-3 with a low affinity [dissociation constant (Kd) of 17.9 ± 3.6 nM]. No consensus sequence for a tyrosine kinase was present in the cytoplasmic domain. Thus, additional components are required for a functional high affinity IL-3 receptor. A sequence comparison of the IL-3 receptor with other cytokine receptors (erythropoietin, IL-4, IL-6, and the β chain IL-2 receptor) revealed a common motif of a distinct receptor gene family.

引用

页码：324 / 327

页数：4

共 47 条

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