HEPATOCYTE GROWTH-FACTOR HAS POTENT ANTIPROLIFERATIVE ACTIVITY IN VARIOUS TUMOR-CELL LINES

被引:232
作者
TAJIMA, H [1 ]
MATSUMOTO, K [1 ]
NAKAMURA, T [1 ]
机构
[1] KYUSHU UNIV,FAC SCI,DEPT BIOL,FUKUOKA 812,JAPAN
关键词
HEPATOCYTE GROWTH FACTOR (HGF); ANTITUMOR AGENT; GROWTH INHIBITION; HGF RECEPTOR;
D O I
10.1016/0014-5793(91)81291-F
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Hepatocyte growth factor (HGF) has potent mitogenic activity for mature hepatocytes and various normal epithelial cells. We now have evidence that HGF at 1-10 ng/ml, strongly inhibits the growth of HepG2 hepatocellular carcinoma cells, B6/F1 melanoma cells and KB squamous carcinoma cells. These tumor cells express high affinity receptors for HGF with a K(d) of 25-28 pM, similar to findings with hepatocytes. HGF at 1-100 ng/ml had no significant cytolytic effect on tumor cells. Therefore, the anti-proliferative effect of HGF on tumor cells seems to be cytostatic, not cytolytic. As HGF apparently has bidirectional effects on cell growth, the possibility that it can serve as an anti-tumor agent merits attention.
引用
收藏
页码:229 / 232
页数:4
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