SUPPRESSION OF OCULAR HERPES RECURRENCES BY A THYMIDINE KINASE INHIBITOR IN SQUIRREL-MONKEYS

被引：17

作者：

KAUFMAN, HE

VARNELL, ED

CHENG, YC

BOBEK, M

THOMPSON, HW

DUTSCHMAN, GE

机构：

[1] YALE UNIV, SCH MED, DEPT PHARMACOL, NEW HAVEN, CT 06510 USA

[2] ROSWELL PK CANC INST, GRACE CANC DRUG CTR, BUFFALO, NY USA

来源：

ANTIVIRAL RESEARCH | 1991年 / 16卷 / 03期

关键词：

DENDRITIC KERATITIS; HERPES SIMPLEX VIRUS; RECURRENT OCULAR HERPETIC DISEASE; THYMIDINE KINASE; VIRUS INHIBITOR;

D O I：

10.1016/0166-3542(91)90002-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

5'-Ethynylthymidine, an inhibitor of viral thymidine kinase (TK), was given intraperitoneally to squirrel monkeys previously infected by the ocular route with Rodanus strain herpes simplex virus. Spontaneous ocular recurrences were reduced during therapy, compared to saline-treated controls. This is the first in vivo demonstration that a viral TK inhibitor can reduce recurrences of HSV-1. Similar benefit would be expected for HSV-2 and perhaps VZV (varicella zoster virus).

引用

页码：227 / 232

页数：6

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