ESTIMATION OF ELASTIC RECOVERY, WORK OF DECOMPRESSION AND YOUNGS MODULUS USING A ROTARY TABLET PRESS

被引：34

作者：

DWIVEDI, SK ^{[1
]}

OATES, RJ ^{[1
]}

MITCHELL, AG ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,FAC PHARMACEUT SCI,2146 E MALL,VANCOUVER V6T 1Z3,BC,CANADA

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1992年 / 44卷 / 06期

关键词：

D O I：

10.1111/j.2042-7158.1992.tb03647.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Capping and lamination occur when the bonds within a tablet cannot withstand the elastic recovery during decompression. To estimate tablet recovery, it is necessary to subtract the machine recovery from the total recovery during decompression. A direct relationship between the force and machine deformation is applied in a novel fashion to calculate in-die tablet recovery on a Manesty Betapress and to estimate the Young's modulus, E, of various solids from the recovery data. The E values of about twenty-five pharmaceutical solids were found to be in reasonable agreement with literature values. This procedure allows in-process analysis of tablet recovery and gives E without the use of specialized equipment.

引用

页码：459 / 466

页数：8

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