IN-VITRO ACTIVITY OF TRIMETHOPRIM IN ASSOCIATION WITH SULFIMIDAZOLE AGAINST AEROBIC GRAM-NEGATIVE AND GRAM-POSITIVE MICROORGANISMS AND CLOSTRIDIA

被引:3
作者
CASTELLI, M
BAGGIO, G
RUBERTO, AI
ROSSI, T
PROVVISIONATO, A
MALAGOLI, M
BOSSA, R
GALATULAS, I
机构
[1] UNIV MODENA,DEPT BIOMED SCI,HYG & MICROBIOL SECT,I-41100 MODENA,ITALY
[2] UNIV MODENA,DEPT PHARMACEUT SCI,I-41100 MODENA,ITALY
[3] UNIV MILAN,DEPT PHARMACOL CHEMOTHERAPY & TOXICOL,MILAN,ITALY
关键词
SULFIMIDAZOLE; TRIMETHOPRIM; ANTIBACTERIAL ACTIVITY; AEROBIC MICROORGANISMS; CLOSTRIDIA;
D O I
10.1159/000239365
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The in vitro activity of a chemotherapeutic agent, sulfimidazole (SIZ), obtained by combining two molecules belonging to groups of extremely different antibacterial drugs, p-aminobenzene sulfonamide and a derivative with a 5-nitroimidazole ring, was studied. In association with trimethoprim, SIZ induces an intense synergistic antibacterial effect on gramnegative and gram-positive aerobic microorganisms and Clostridia. The results show that, in SIZ, the activity of each starting molecule remains unchanged providing that its structureaction relationship is kept intact.
引用
收藏
页码:337 / 344
页数:8
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