DIRECT SEPARATION OF 4-AMINO-3-(4-CHLOROPHENYL)BUTYRIC ACID AND ANALOGS, GABA(B) LIGANDS, USING A CHIRAL CROWN-ETHER STATIONARY-PHASE

被引：17

作者：

VACCHER, C ^{[1
]}

BERTHELOT, P ^{[1
]}

DEBAERT, M ^{[1
]}

机构：

[1] UNIV LILLE II,PHARM CHIM LAB,BP 83,3 RUE PR LAGUESSE,F-59006 LILLE,FRANCE

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 645卷 / 01期

关键词：

D O I：

10.1016/0021-9673(93)80622-F

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The direct resolution of baclofen (beta-p-chlorophenyl-gamma-aminobutyric acid) and a series of four analogues was achieved by HPLC on an enantioselective crown ether column, CR(+). Chromatography was carried out with perchloric acid as mobile phase and methanol as organic modifier. The effects of temperature, pH, eluent composition and substituents are discussed. The absolute configuration is attributed. The best results were obtained with baclofen (alpha = 1.48; R(s) = 8.07).

引用

页码：95 / 99

页数：5

共 25 条

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