ALTERED FIBRONECTIN-DEPENDENT CELL-ADHESION BY PDGF ACCOMPANIES PHENOTYPIC MODULATION OF VASCULAR SMOOTH-MUSCLE CELLS

被引：13

作者：

FUJIO, Y

YAMADA, F

TAKAHASHI, K

SHIBATA, N

机构：

[1] Center for Adult Dtscases. Osaka, Higashinari Ku Osaka 537

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 196卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.2348

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

PDGF promotes growth of smooth muscle cells (SMCs) and induces morphological changes. We investigated the effects of PDGF on cell-matrix adhesion of SMCs. PDGF reorganized integrin distribution as well as actin filament structure. PDGF-treated cells attached more loosely to fibronectin than non-treated cells. Decreased expression of α-actin by PDGF was antagonized by coating culture dishes with fibronectin but not with vitronectin and laminin. The inhibition of cell adhesion by GRGDSP oligopeptide and anti-fibronectin receptor antibody led to the reduction in α-actin expression. These results suggest that PDGF may modulate phenotype of SMCs by altering fibronectin-integrin interaction. © 1993 Academic Press, Inc.

引用

页码：997 / 1002

页数：6

共 15 条

[1] CHANGES IN KERATINOCYTE ADHESION DURING TERMINAL DIFFERENTIATION - REDUCTION IN FIBRONECTIN BINDING PRECEDES ALPHA-5-BETA-1-INTEGRIN LOSS FROM THE CELL-SURFACE [J].