THE GAMMA-SUBUNIT OF THE ACETYLCHOLINE-RECEPTOR IS NOT EXPRESSED IN THE LEVATOR PALPEBRAE SUPERIORIS

被引：27

作者：

KAMINSKI, HJ ^{[1
]}

KUSNER, LL ^{[1
]}

NASH, KV ^{[1
]}

RUFF, RL ^{[1
]}

机构：

[1] CLEVELAND VET AFFAIRS MED CTR, CLEVELAND, OH USA

来源：

NEUROLOGY | 1995年 / 45卷 / 03期

关键词：

D O I：

10.1212/WNL.45.3.516

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

In extraocular muscle (EOM), expression of the gamma-subunit, which is associated with the fetal-type acetylcholine receptor (AChR), may offer a differential target for immune-mediated damage and could explain the preponderance of ocular manifestations caused by myasthenia gravis (MG). Using Poly(A)(+) RNA hybridization, we investigated expression of the gamma-subunit in bovine levator palpebrae superioris (LP), a muscle also differentially involved by MG. There were no transcripts of the gamma-subunit of the AChR, but the epsilon-subunit, associated with the adult-type AChR, tvas present. The results indicate that the susceptibility of LP to MG is not mediated by gamma-subunit expression and suggest that multiterminal fibers in EOM may be the site of gamma-subunit expression.

引用

页码：516 / 518

页数：3

共 13 条

[1] ACETYLCHOLINE-RECEPTOR CHANNELS ON ADULT-MOUSE SKELETAL-MUSCLE ARE FUNCTIONALLY IDENTICAL IN SYNAPTIC AND NONSYNAPTIC MEMBRANE [J].