Schwannomin: New insights into this member of the band 4.1 superfamily

被引：5

作者：

Belliveau, MJ

Lutchman, M

Claudio, JO

Marineau, C

Rouleau, GA

机构：

[1] MONTREAL GEN HOSP, RES INST, MONTREAL, PQ H3G 1A4, CANADA

[2] MCGILL UNIV, NEUROSCI RES CTR, MONTREAL, PQ H3A 2T5, CANADA

来源：

BIOCHEMISTRY AND CELL BIOLOGY | 1995年 / 73卷 / 9-10期

关键词：

NF2; band; 4.1; tumour suppressor; cytoskeleton;

D O I：

10.1139/o95-081

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurofibromatosis type 2 (NF2) is an autosomal dominant disease characterized by the development of central nervous system tumours. The NM gene was recently cloned and found to encode a protein, schwannomin (or merlin), with homology to the band 4.1 superfamily. This superfamily of proteins includes ezrin, moesin, radixin, and talin, as well as several protein tyrosine phosphatases. How does a cytoskeleton-associated protein act as a tumour suppressor? While this fundamental question remains unanswered, recent studies have begun to address key questions regarding the function of schwannomin. In this review, we examine what is known about the band 4.1 superfamily and how this information pertains to schwannomin. In addition, we summarize recent studies of schwannomin itself.

引用

收藏

页码：733 / 737

页数：5

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