THE SYNTHESIS OF 5-SUBSTITUTED-2,4-DIMETHOXYPYRIMIDINES AND SOME RELATED NUCLEOSIDE ANALOGS

被引：8

作者：

WHALE, RF ^{[1
]}

COE, PL ^{[1
]}

WALKER, RT ^{[1
]}

机构：

[1] UNIV BIRMINGHAM, SCH CHEM, BIRMINGHAM B15 2TT, W MIDLANDS, ENGLAND

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1992年 / 11卷 / 07期

关键词：

D O I：

10.1080/07328319208021184

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The reaction of 5-formyl-2,4-dimethoxypyrimidine with active methylene compounds in the Knoevenagel reaction and the subsequent nucleoside formation reactions of some of the products was investigated. A new synthesis of (E)-5-(2-bromovinyl)uracil and an improved synthesis of 5-formyl-2',3'-isopropylidene uridine are reported.

引用

页码：1425 / 1442

页数：18

共 32 条

[1] ARMSTRONG VW, 1986, NUCLEIC ACID CHEM, V3, P65
[2] Baer H.H., 1970, CHEM NITRO NITROSO 2, P75
[3] SYNTHESIS OF SOME 5-HALOGENOVINYL DERIVATIVES OF URACIL AND THEIR CONVERSION INTO 2'-DEOXYRIBONUCLEOSIDES
BARR, PJ
JONES, AS
VERHELST, G
WALKER, RT
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1981, (06): : 1665 - 1670
[4] PYRIDO[2,3-D]PYRIMIDINE NUCLEOSIDES - SYNTHESIS VIA CYCLIZATION OF C-5-SUBSTITUTED CYTIDINES
BERGSTROM, DE
INOUE, H
REDDY, PA
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1982, 47 (11) : 2174 - 2178
[5] C-5 SUBSTITUTED PYRIMIDINE NUCLEOSIDES .2. SYNTHESIS VIA OLEFIN COUPLING TO ORGANOPALLADIUM INTERMEDIATES DERIVED FROM URIDINE AND 2'-DEOXYURIDINE
BERGSTROM, DE
OGAWA, MK
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (26) : 8106 - 8112
[6] BLEACKLEY RC, 1976, TETRAHEDRON, V32, P2795, DOI 10.1016/0040-4020(76)80125-1
[7] COOKSON RC, 1985, EUR J MED CHEM, V20, P375
[8] AN EFFICIENT METHOD FOR THE IODINATION OF C-5-POSITION OF DIALKOXY PYRIMIDINES AND URACIL BASES
DAS, B
KUNDU, NG
[J]. SYNTHETIC COMMUNICATIONS, 1988, 18 (08) : 855 - 867
[9] SYNTHESIS AND ANTIVIRAL PROPERTIES OF 5-VINYLPYRIMIDINE NUCLEOSIDE ANALOGS
DECLERCQ, E
WALKER, RT
[J]. PHARMACOLOGY & THERAPEUTICS, 1984, 26 (01) : 1 - 44
[10] DECLERCQ E, 1979, P NATL ACAD SCI USA, V76, P2947, DOI 10.1073/pnas.76.6.2947

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