THE SYNTHESIS OF 5-SUBSTITUTED-2,4-DIMETHOXYPYRIMIDINES AND SOME RELATED NUCLEOSIDE ANALOGS

被引：8

作者：

WHALE, RF ^{[1
]}

COE, PL ^{[1
]}

WALKER, RT ^{[1
]}

机构：

[1] UNIV BIRMINGHAM, SCH CHEM, BIRMINGHAM B15 2TT, W MIDLANDS, ENGLAND

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 1992年 / 11卷 / 07期

关键词：

D O I：

10.1080/07328319208021184

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The reaction of 5-formyl-2,4-dimethoxypyrimidine with active methylene compounds in the Knoevenagel reaction and the subsequent nucleoside formation reactions of some of the products was investigated. A new synthesis of (E)-5-(2-bromovinyl)uracil and an improved synthesis of 5-formyl-2',3'-isopropylidene uridine are reported.

引用

页码：1425 / 1442

页数：18