THE PATHOGENESIS OF VACUOLES PRODUCED IN RAT AND MOUSE-LIVER CELLS BY A CONJUGATE OF ADENINE-ARABINOSIDE MONOPHOSPHATE WITH LACTOSAMINATED ALBUMIN

被引：20

作者：

FIUME, L ^{[1
]}

BETTS, CM ^{[1
]}

BUSI, C ^{[1
]}

CORZANI, S ^{[1
]}

DERENZINI, M ^{[1
]}

DISTEFANO, G ^{[1
]}

MATTIOLI, A ^{[1
]}

机构：

[1] UNIV BOLOGNA,DEPT EXPTL PATHOL,I-40126 BOLOGNA,ITALY

来源：

JOURNAL OF HEPATOLOGY | 1992年 / 15卷 / 03期

关键词：

LIVER TARGETING; ANTIVIRAL DRUGS; LACTOSAMINATED ALBUMIN; CHRONIC HEPATITIS-B;

D O I：

10.1016/0168-8278(92)90062-T

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

A conjugate of adenine arabinoside monophosphate with lactosaminated albumin produced vacuoles in hepatic cells of rats and mice when given at doses 5- 10 times higher than that (35 mg/kg) capable of inhibiting hepatitis B virus replication in patients with chronic hepatitis B. The vacuoles were due to the swelling of secondary lysosomes probably caused by incapacity of the lysosomal enzymes to rapidly digest large amounts of conjugate into products able to cross the lysosomal membrane. Although vacuoles progressively disappeared when conjugate administration was discontinued, the present observation suggests caution in giving the conjugate to man at daily doses higher than 35 mg/kg.

引用

页码：314 / 322

页数：9

共 26 条

[11] ADENINE-ARABINOSIDE MONOPHOSPHATE (VIDARABINE PHOSPHATE) IN COMBINATION WITH HUMAN-LEUKOCYTE INTERFERON IN THE TREATMENT OF CHRONIC HEPATITIS-B - A RANDOMIZED, DOUBLE-BLINDED, PLACEBO-CONTROLLED TRIAL [J].