IN-VITRO EVALUATION OF THE ANTI-PICORNAVIRUS ACTIVITIES OF NEW SYNTHETIC FLAVONOIDS

被引：21

作者：

DESIDERI, N ^{[1
]}

CONTI, C ^{[1
]}

SESTILI, I ^{[1
]}

TOMAO, P ^{[1
]}

STEIN, ML ^{[1
]}

ORSI, N ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,SCH MED,INST MICROBIOL,I-00185 ROME,ITALY

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1995年 / 6卷 / 05期

关键词：

ANTI-POLIOVIRUS ACTIVITY; ANTIRHINOVIRUS ACTIVITY; FLAVONOIDS;

D O I：

10.1177/095632029500600503

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Substituted oxazolinylflavons and oxazolinylflavanones were synthesized in order to compare their anti-picornavirus activities with those of related natural and synthetic compounds. The antiviral potencies of the new compounds were evaluated against rhinovirus type 1B and poliovirus type 2 by a plaque reduction assay in HeLa cell cultures. Among the substituted flavanones only 6-chloro-4'-oxazolinylflavanone showed activity against both viruses. A comparison of the effects of 3-substituted flavones indicated that the presence of a 3-methoxy group enhances the activity against rhinovirus, while the presence of a 3-hydroxy group enhances the activity against poliovirus.

引用

页码：298 / 306

页数：9

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