AN ANTIGEN-PROCESSING POLYMORPHISM REVEALED BY HLA-B8-RESTRICTED CYTOTOXIC T-LYMPHOCYTES WHICH DOES NOT CORRELATE WITH TAP GENE POLYMORPHISM

被引：31

作者：

ROWLANDJONES, SL ^{[1
]}

POWIS, SH ^{[1
]}

SUTTON, J ^{[1
]}

MOCKRIDGE, I ^{[1
]}

GOTCH, FM ^{[1
]}

MURRAY, N ^{[1
]}

HILL, AB ^{[1
]}

ROSENBERG, WM ^{[1
]}

TROWSDALE, J ^{[1
]}

MCMICHAEL, AJ ^{[1
]}

机构：

[1] IMPERIAL CANC RES FUND,LONDON WC2A 3PX,ENGLAND

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1993年 / 23卷 / 08期

关键词：

ANTIGEN PROCESSING AND PRESENTATION; HLA-B8; TAP-1 AND TAP-2 GENES;

D O I：

10.1002/eji.1830230841

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In previous studies of antigen presentation through HLA-B27. we identified a healthy person whose lymphoblastoid cells do not present three B27-restricted viral epitopes to specific cytotoxic T lymphocytes (CTL), despite adequate cell surface expression of HLA-B2702 of normal sequence. Similar findings were observed in all members of his family sharing the HLA-A3-B2702 haplotype.The original donor, NW, carries HLA-B8 on his other class I haplotype, which his daughter, HW, has inherited. We now report a failure to present an HLA-B8-restricted epitope from influenza nucleoprotein following viral infection of NW cells, although exogenous added peptide is still presented normally. However, cells from HW, which do not carry the A3-B2702 haplotype. present the expected epitope after viral infection. Another B8-restricted epitope. from human immunodeficiency virus-gag, is presented equally well by both cell lines when infected with gag-vaccinia. This antigen processing phenotype does not correlate with any of the known human TAP-1 and TAP-2 polymorphisms.

引用

页码：1999 / 2004

页数：6

共 41 条

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