PEPTIDE LIGASES - TOOLS FOR PEPTIDE-SYNTHESIS

被引：18

作者：

JAKUBKE, HD

机构：

[1] Institut für Biochemie, Fakultät für Biowissenschaften, Pharmazie und Psychologie, Universität Leipzig, D-04103

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1995年 / 34卷 / 02期

关键词：

CATALYTIC ANTIBODIES; LIGASES; PEPTIDE SYNTHESIS; RNASE A; SUBTILISIN;

D O I：

10.1002/anie.199501751

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Since the ligation of peptide fragments in vivo is meaningless, no natural enzyme is capable of replacing chemical coupling methods, which have the danger of racemization in segment condensation. Native proteases and those altered by protein design as well as catalytic antibodies may serve as peptide ligases, as demonstrated recently with subtiligase in the chemoenzymatic synthesis of R Nase A. Copyright © 1995 by VCH Verlagsgesellschaft mbH, Germany

引用

页码：175 / 177

页数：3