TRANSMEMBRANE HELICAL INTERACTIONS AND THE ASSEMBLY OF THE T-CELL RECEPTOR COMPLEX

被引：209

作者：

MANOLIOS, N

BONIFACINO, JS

KLAUSNER, RD

机构：

[1] Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda

来源：

SCIENCE | 1990年 / 249卷 / 4966期

关键词：

D O I：

10.1126/science.2142801

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Studies of the subunit interactions of the multicomponent T cell antigen receptor (TCR) revealed that specific pairs of chains have the ability to assemble after transfection into fibroblasts. For one such pair, TCR-α and CD3-δ, their ability to assemble was encoded by their transmembrane domains. The specificity of this interaction suggests that well-defined helical interactions in the membrane can explain the assembly of some multichain membrane complexes.

引用

页码：274 / 277

页数：4

共 29 条

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