TRANSMEMBRANE HELICAL INTERACTIONS AND THE ASSEMBLY OF THE T-CELL RECEPTOR COMPLEX

被引:209
作者
MANOLIOS, N
BONIFACINO, JS
KLAUSNER, RD
机构
[1] Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda
关键词
D O I
10.1126/science.2142801
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Studies of the subunit interactions of the multicomponent T cell antigen receptor (TCR) revealed that specific pairs of chains have the ability to assemble after transfection into fibroblasts. For one such pair, TCR-α and CD3-δ, their ability to assemble was encoded by their transmembrane domains. The specificity of this interaction suggests that well-defined helical interactions in the membrane can explain the assembly of some multichain membrane complexes.
引用
收藏
页码:274 / 277
页数:4
相关论文
共 29 条
[11]  
HENDERSON R, 1975, NATURE, V273, P443
[12]  
HURTLEY SM, 1989, ANN REV CELL BIOL, V5, P227
[13]   SURFACE EXPRESSION OF THE T-CELL RECEPTOR COMPLEX REQUIRES CHARGED RESIDUES WITHIN THE ALPHA-CHAIN TRANSMEMBRANE REGION [J].
JOHN, S ;
BANTING, GS ;
GOODFELLOW, PN ;
OWEN, MJ .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1989, 19 (02) :335-339
[14]   CHARACTERIZATION OF MONOCLONAL-ANTIBODIES AGAINST CHLAMYDOMONAS FLAGELLAR DYNEINS BY HIGH-RESOLUTION PROTEIN BLOTTING [J].
KING, SM ;
OTTER, T ;
WITMAN, GB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (14) :4717-4721
[15]  
KLAUSNER R D, 1989, New Biologist, V1, P3
[16]   THE ISOLATION AND NUCLEOTIDE-SEQUENCE OF A CDNA-ENCODING THE T-CELL SURFACE PROTEIN-T4 - A NEW MEMBER OF THE IMMUNOGLOBULIN GENE FAMILY [J].
MADDON, PJ ;
LITTMAN, DR ;
GODFREY, M ;
MADDON, DE ;
CHESS, L ;
AXEL, R .
CELL, 1985, 42 (01) :93-104
[17]   THE LYSINE RESIDUE IN THE MEMBRANE-SPANNING DOMAIN OF THE BETA-CHAIN IS NECESSARY FOR CELL-SURFACE EXPRESSION OF THE T-CELL ANTIGEN RECEPTOR [J].
MORLEY, BJ ;
CHIN, KN ;
NEWTON, ME ;
WEISS, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1988, 168 (06) :1971-1978
[18]  
PATEL MD, 1987, J BIOL CHEM, V262, P5831
[19]   REGULATION OF PROTEIN EXPORT FROM THE ENDOPLASMIC-RETICULUM [J].
ROSE, JK ;
DOMS, RW .
ANNUAL REVIEW OF CELL BIOLOGY, 1988, 4 :257-288
[20]   A MONOCLONAL-ANTIBODY 7G7/B6, BINDS TO AN EPITOPE ON THE HUMAN INTERLEUKIN-2 (IL-2) RECEPTOR THAT IS DISTINCT FROM THAT RECOGNIZED BY IL-2 OR ANTI-TAC [J].
RUBIN, LA ;
KURMAN, CC ;
BIDDISON, WE ;
GOLDMAN, ND ;
NELSON, DL .
HYBRIDOMA, 1985, 4 (02) :91-102