HMG-COA REDUCTASE INHIBITOR FLUVASTATIN INHIBITS INSECT JUVENILE-HORMONE BIOSYNTHESIS

被引：34

作者：

DEBERNARD, S ^{[1
]}

ROSSIGNOL, F ^{[1
]}

COUILLAUD, F ^{[1
]}

机构：

[1] UNIV BORDEAUX 1,NEUROENDOCRINOL LAB,CNRS,URA 1138,F-33405 TALENCE,FRANCE

来源：

GENERAL AND COMPARATIVE ENDOCRINOLOGY | 1994年 / 95卷 / 01期

关键词：

D O I：

10.1006/gcen.1994.1105

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fluvastatin (Sandoz Compound XU 62-320), a synthetic HMG-CoA reductase inhibitor, was assayed in vitro and in vivo for its ability to suppress juvenile hormone (JH) biosynthesis by corpora allata of Locusta migratoria migratorioides. Fluvastatin inhibited JH biosynthesis by corpora allata in vitro. Exogenous mevalonic acid lactone restored JH biosynthesis in corpora allata inhibited by fluvastatin. Fluvastatin injected into locusts in vivo inhibited JH biosynthesis, but maximal inhibition lasted for only 6 hr. There were no discernible effects on either JH-regulated metamorphosis or oocyte maturation. Lengthening of the fourth larval stadium was observed and increased doses (single or repeated injections) were fatal. (C) 1994 Academic Press, Inc,

引用

页码：92 / 98

页数：7

共 34 条

[1] INVIVO AND INVITRO EFFECTS OF COMPACTIN IN LIPOSOME CARRIERS ON JUVENILE-HORMONE BIOSYNTHESIS IN ADULT FEMALES OF BLATTELLA-GERMANICA [J].

BELLES, X ;

CAMPS, F ;

CASAS, J ;

LLORIA, J ;

MESSEGUER, A ;

PIULACHS, MD ;

SANCHEZ, FJ .

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, 1988, 32 (01) :1-10

[2] JUVENILE-HORMONE ACID SYNTHESIS AND HMG-COA REDUCTASE-ACTIVITY IN CORPORA ALLATA OF MANDUCA-SEXTA PREPUPAE [J].

BHASKARAN, G ;

DAHM, KH ;

JONES, GL ;

PECK, K ;

FAUGHT, S .

INSECT BIOCHEMISTRY, 1987, 17 (07) :933-937

[3]

BROWN MS, 1978, J BIOL CHEM, V253, P1121

[4]

CLAYTON RB, 1964, J LIPID RES, V5, P3

[5] EVIDENCE FOR REGULATION OF JUVENILE-HORMONE BIOSYNTHESIS OPERATING BEFORE MEVALONATE IN LOCUST CORPORA ALLATA [J].

COUILLAUD, F .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1991, 77 (1-3) :159-166

[6] CHARACTERIZATION AND REGULATION OF HMG-COA SYNTHASE IN LOCUSTA-MIGRATORIA CORPORA ALLATA [J].

COUILLAUD, F ;

ROSSIGNOL, F .

ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY, 1991, 18 (04) :273-283

[7] CONTROL OF C-16 JUVENILE-HORMONE BIOSYNTHESIS IN ACTIVE CORPORA ALLATA OF FEMALE AFRICAN LOCUSTS [J].

COUILLAUD, F ;

GIRARDIE, A .

INTERNATIONAL JOURNAL OF INVERTEBRATE REPRODUCTION AND DEVELOPMENT, 1985, 8 (06) :303-315

[8] REGULATION OF JUVENILE-HORMONE TITER IN AFRICAN LOCUST [J].

COUILLAUD, F ;

MAUCHAMP, B ;

GIRARDIE, A .

EXPERIENTIA, 1985, 41 (09) :1165-1167

[9] ASSAY OF HMG-COA SYNTHASE IN DIPLOPTERA-PUNCTATA CORPORA ALLATA [J].

COUILLAUD, F ;

FEYEREISEN, R .

INSECT BIOCHEMISTRY, 1991, 21 (02) :131-135

[10] BIOSYNTHESIS AND TITER OF JUVENILE-HORMONE DURING THE 1ST GONOTROPHIC CYCLE IN ISOLATED AND CROWDED LOCUSTA-MIGRATORIA FEMALES [J].

DALE, JF ;

TOBE, SS .

JOURNAL OF INSECT PHYSIOLOGY, 1986, 32 (09) :763-769

← 1 2 3 4 →