HMG-COA REDUCTASE INHIBITOR FLUVASTATIN INHIBITS INSECT JUVENILE-HORMONE BIOSYNTHESIS

被引：34

作者：

DEBERNARD, S ^{[1
]}

ROSSIGNOL, F ^{[1
]}

COUILLAUD, F ^{[1
]}

机构：

[1] UNIV BORDEAUX 1,NEUROENDOCRINOL LAB,CNRS,URA 1138,F-33405 TALENCE,FRANCE

来源：

GENERAL AND COMPARATIVE ENDOCRINOLOGY | 1994年 / 95卷 / 01期

关键词：

D O I：

10.1006/gcen.1994.1105

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fluvastatin (Sandoz Compound XU 62-320), a synthetic HMG-CoA reductase inhibitor, was assayed in vitro and in vivo for its ability to suppress juvenile hormone (JH) biosynthesis by corpora allata of Locusta migratoria migratorioides. Fluvastatin inhibited JH biosynthesis by corpora allata in vitro. Exogenous mevalonic acid lactone restored JH biosynthesis in corpora allata inhibited by fluvastatin. Fluvastatin injected into locusts in vivo inhibited JH biosynthesis, but maximal inhibition lasted for only 6 hr. There were no discernible effects on either JH-regulated metamorphosis or oocyte maturation. Lengthening of the fourth larval stadium was observed and increased doses (single or repeated injections) were fatal. (C) 1994 Academic Press, Inc,

引用

页码：92 / 98

页数：7

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