EFFECT OF POTATO GLYCOALKALOIDS ALPHA-CHACONINE AND ALPHA-SOLANINE ON SODIUM ACTIVE-TRANSPORT IN FROG-SKIN

被引：36

作者：

BLANKEMEYER, JT ^{[1
]}

ATHERTON, R ^{[1
]}

FRIEDMAN, M ^{[1
]}

机构：

[1] USDA ARS, WESTERN REG RES CTR, FOOD SAFETY & HLTH RES UNIT, ALBANY, CA 94710 USA

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 1995年 / 43卷 / 03期

关键词：

ALPHA-CHACONINE; FOOD SAFETY; FROG SKIN; GLYCOALKALOIDS; MEMBRANE POTENTIAL; POTATOES; SHORT-CIRCUIT CURRENT; SODIUM ION TRANSPORT; ALPHA-SOLANINE;

D O I：

10.1021/jf00051a015

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

To test the effect of glycoalkaloids on sodium ion active transport, frog skin was exposed to the potato glycoalkaloids alpha-chaconine and alpha-solanine in a glass Ussing chamber. It was found that the short-circuit current (ISC), the measure of transepithelial active transport of sodium, decreased up to 30% at an alpha-chaconine concentration of 10 mg/L. alpha-Solanine had a similar but smaller effect, decreasing short-circuit current by 16%. The data suggest that (a) frog skin is a useful experimental model to evaluate effects of glycoalkaloids at the cellular level and (b) the mechanism of action of the two glycoalkaloids is to modify the active transport of sodium. The possible significance of these findings to food safety is discussed.

引用

页码：636 / 639

页数：4

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