INCREASED P53 SITE-SPECIFIC DNA-BINDING IN CELLS PRODUCING MUTANT P53

被引：4

作者：

DEES, C

TRAVIS, CC

机构：

[1] Molecular Toxicology Group, Health Sciences Research Division, Oak Ridge National Laboratory, Oak Ridge, TN 37831-6109, Bldg. 4500S/MS-6109

来源：

CANCER LETTERS | 1995年 / 96卷 / 02期

关键词：

P53; ACTIVATING MUTATIONS; CHEMOTHERAPY; MUTAGENS; TUMOR VIRULENCE;

D O I：

10.1016/0304-3835(95)03936-Q

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chemotherapeutic and DNA-damaging agents were found to increase p53 site-specific DNA binding in human breast and rat liver epithelial WBrasII cells which produce mutant p53. Increased p53 site-specific DNA-binding by chemotherapeutic or DNA-damaging agents was also induced in transfected Saos-2 cells producing wild type or transforming mutant p53. Therefore, exposure of cells containing a transforming p53 mutant to chemotherapeutic or DNA-damaging agents may potentially enhance their transformation state and tumorigenic potential.

引用

页码：225 / 231

页数：7

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