SYNTHESIS OF THE TOPOISOMERASE-II INHIBITOR BE-10988

被引:14
作者
MOODY, CJ
SWANN, E
机构
[1] Department of Chemistry, Loughborough University of Technology, Loughborough
关键词
D O I
10.1016/S0040-4039(00)91982-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The naturally occurring indolequinone BE 10988 1, an inhibitor of topoisomerase II, has been synthesised in an overall yield of 28%.
引用
收藏
页码:1987 / 1988
页数:2
相关论文
共 11 条
[1]  
EPSTEIN RJ, 1988, LANCET, P521
[2]  
JONE SGB, 1989, THESIS U LONDON
[3]   STRUCTURALLY MODIFIED ANTITUMOUR AGENTS .2. TOTAL SYNTHESIS OF A CYCLOPROPAMITOSENE [J].
JONES, GB ;
MOODY, CJ .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1989, (12) :2455-2462
[4]   SYNTHESIS OF THE CARBAZOLE ALKALOID MURRAYAQUINONE-B [J].
MARTIN, T ;
MOODY, CJ .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1988, (02) :241-246
[5]   ERGOLINE SYNTHONS - SYNTHESIS OF 3,4-DIHYDRO-6-METHOXYBENZ[CD]INDOL-5(1H)-ONE (6-METHOXY-UHLE KETONE) AND 3,4-DIHYDROBENZ[CD]INDOL-5(1H)-ONE (UHLE KETONE) VIA A NOVEL DECARBOXYLATION OF INDOLE-2-CARBOXYLATES [J].
MEYER, MD ;
KRUSE, LI .
JOURNAL OF ORGANIC CHEMISTRY, 1984, 49 (17) :3195-3199
[6]   A NEW TOPOISOMERASE-II INHIBITOR, BE-10988, PRODUCED BY A STREPTOMYCETE .1. TAXONOMY, FERMENTATION, ISOLATION AND CHARACTERIZATION [J].
OKA, H ;
YOSHINARI, T ;
MURAI, T ;
KAWAMURA, K ;
SATOH, F ;
FUNAISHI, K ;
OKURA, A ;
SUDA, H ;
OKANISHI, M ;
SHIZURI, Y .
JOURNAL OF ANTIBIOTICS, 1991, 44 (05) :486-491
[7]  
OSULLIVAN N, 1992, THESIS LOUGHBOROUGH
[8]   DNA TOPOISOMERASES AS TARGETS FOR CANCER-THERAPY [J].
ROSS, WE .
BIOCHEMICAL PHARMACOLOGY, 1985, 34 (24) :4191-4195
[9]  
SASAKI T, 1976, TETRAHEDRON, V32, P437, DOI 10.1016/0040-4020(76)80059-2
[10]   STRUCTURE OF A NEW TOPOISOMERASE-II INHIBITOR BE-10988 [J].
SUDA, H ;
MATSUNAGA, K ;
YAMAMURA, S ;
SHIZURI, Y .
TETRAHEDRON LETTERS, 1991, 32 (24) :2791-2792